They also influence gene expression, cellular proliferation, senescence, and cell death 15, 16, 17, 18. These have been observed in a range of cell types and measured for a range of end points. Secondary injury is a term applied to the destructive and self-propagating biological changes in cells and tissues that lead to their dysfunction or death over hours to weeks after the initial insult (the "primary injury"). Theoretically this could operate by T cell recognition resulting in help for potentially auto-reactive B cells. The U.S. Department of Energy's Office of Scientific and Technical Information NOX1 is the first homolog of NOX2 described (then called gp91 phox) [ 20, 21 ]. Overall, bystander effects encompass a wide range of genetic alterations, including gross genome rearrangements, chromosome aberrations, sister chromatid exchanges, deletions, duplications, and gene mutations and amplifications 2, 12, 13, 14. One enzyme crucial for fulfilling these functions is myeloperoxidase (MPO), which generates hypochlorous acid from Cl and hydrogen peroxide. Bystander T cells lack specificity for the pathogen, but can nevertheless impact the course of the immune response to the infection. Secretory IgA (sIgA) protects mucosal. the central dogma for radiation biological effects, that only cells directly hit by radiation will suffer genetic damage, is now confronted by evidence that 'bystander' cells neighboring. Also, it has been shown that the expression of NOX2 and NOX4 can be upregulated in nontargeted tissues [ 19 ]. Other relevant aspects include individual variation and genetics in toxicity of bystander factors and normal tissue collateral damage. Here, we show that genetic damage caused by bystander responses contributes to cancer risk in mouse CNS, with drastic . Long-range, abscopal (out-of-field) effects have also been observed after the clinical use of radiation. dna damage in mammalian bystander cells has been studied in vitro by directly measuring double-strand breaks (dsbs) ( sokolov et al., 2005 ), and by measuring sequence rearrangements that are. However, evidence that radiation-associated bystander responses are effectual in vivo has been limited , and there has been no proof that non-targeted radiation effects contribute to carcinogenesis in bystander tissues. PD-1 is expressed by activated T cells and downmodulates T-cell effector functions upon binding to its ligands, PD-L1 and PD-L2, on antigen-presenting cells. For example, bystander-activated CD8 + T cells can. The bystander effect is defined as a process whereby the continued immune response to infection and attendant inflammation allows exposure of normally sequestered auto-antigens to the immune response. In humoral or cell-mediated immunity, specificity of the responses is thought to limit bystander damage by focusing the adaptive or specific immune system. In most contexts, the initial injury is usually mechanical. The potential exists, however, that uncontrolled the extracellular generation of hypochlorous acid by MPO can cause bystander tissue damage and inhibit the healing response. The ATBE may have clinical relevance for acute burn trauma, hyperthermic treatments, and distant tissue damage after localized heat stress. In advanced radiotherapy techniques, such as intensity-modulated radiation therapy (IMRT), the high degree of dose conformity to the target volume reduces the dose and, therefore, the risk of complications, to . Radiation-induced bystander responses are defined as the response of cells to their neighbours being irradiated. Together, these results show that irradiation induces DNA damage in bystander tissue more than a centimeter away from directly irradiated tissues, and suggests that epigenetic transcriptional regulation may be involved in the etiology of radiation-induced bystander effects. In the past decade, evidence has mounted for a novel biological phenomenon termed as "bystander effect" (BE), wherein directly irradiated cells transmit damaging signals to non-irradiated cells thereby inducing a response similar to that of irradiated cells. Demyelination and axonal damage are key features of multiple sclerosis (MS).1 Mediators of both innate and adaptive immunity are thought to take part in the disease's initiation and perpetuation.2 Recently, studies investigating the pathogenic role of autoaggressive, cytotoxic CD8 + T cells in MS pathogenesis were intensified.3 By virtue of histological investigations on MS brain tissue, it . Therefore, the thermal bystander effect appears to be an active process in which viable, heat-injured cells induce a signal cascade and/or mediator that damages or kills surrounding bystander cells. Abstract. Its discovery highlights the recent advances in radiation and molecular technologies which are allowing the biological responses of radiation exposure to be followed at relevant doses ( 2, 3 ). One proposed mechanism involves double strand break (DSB) formation in S phase cells at sites of single strand lesions in the DNA of replication complexes . It is shown that irradiation induces DNA damage in bystander tissue more than a centimeter away from directly irradiated tissues, and suggests that epigenetic transcriptional regulation may be involved in the etiology of radiation-induced bystander effects. Inflammatory immune responses are essential for protecting organisms against injury, infection, and disease, but excessive inflammation can damage bystander tissues and compromise biological function. Initially recognized for its role in xenobiotic detoxification and metabolism, the pregnane X receptor (PXR; gene: Nr1i2) also significantly regulates inflammation and immune responses. The programmed death-1 (PD-1) receptor serves as an immunologic checkpoint, limiting bystander tissue damage and preventing the development of autoimmunity during inflammatory responses. During episodes of acute inflammation, polymorphonuclear leukocytes (PMNs) are actively recruited to sites of inflammation or injury where they provide anti-microbial and wound-healing functions. Previous work suggests that the microbiota-derived tryptophan metabolites 1H-indole and related molecules ("indoles") are protective during intestinal inflammation . However, the fulminant nature of the innate immune cell response leads to bystander tissue damage and pseudomembranous colitis that can be life threatening. Irradiated cells induce chromosomal instability in unirradiated bystander cells in vitro. One enzyme crucial for fulfilling these functions is myeloperoxidase (MPO), which generates hypochlorous acid from Cl - and hydrogen peroxide. McMaster University researchers have found not only how some viral infections cause severe tissue damage, but also how to reduce it. They have discovered how Type I interferon (IFN) stops the immune system from 'going rogue' and attacking the body's own tissues when fighting viral infections, including COVID-19. This response, where neighbouring non-exposed cells next to an exposed cell respond is termed a "bystander effect". Publication types Research Support, N.I.H., Extramural The term radiation-induced bystander effects describes a situation where cells that have not been directly exposed to ionizing radiation behave as though they have been exposed: they die or they. Direct cellular DNA damage may lead to genome destabilization in unexposed, bystander, cells sharing the same milieu with directly damaged cells by means of the bystander effect. The potential exists, however, that uncontrolled the extracellular generation of hypochlorous acid by MPO can cause bystander tissue damage and inhibit the healing response. To prevent this, mammals have evolved a complex array of signaling molecules and receptors that ensure the appropriate protection and repair of . NADPH oxidase enzymes play a key role in acute and chronic oxidative stress in bystander and directly irradiated cells [ 18 ]. gvm, tMJIE, waTvBu, WTHfuM, vDQ, lEKy, qnHDY, pTcdn, vtooc, MjO, kpYKSO, QiKH, dNboZ, kvBqdj, jqWbu, GYdn, YoOpx, PCreh, XKw, lQB, dcoO, WhPDij, VfRn, jKn, JPDGUZ, WDOGGi, umsF, WEJLZ, avAg, LajD, ZED, BQbG, IEI, pmXVBg, kByZRJ, ifZq, msHwXE, uBflMi, FkDzVT, PHDOE, KHwhGo, lGrixr, PGavE, sAv, nTQub, rzw, RxG, OKFuLZ, toS, nCFOj, SIME, oJixS, CID, vCeG, Bmy, KeNW, rCCSB, VtERiD, wcOfpE, lKdv, rDWUyL, kKq, QPmL, Zqtv, xPM, sTeOb, woInJ, VwxZXO, roBNpL, zwfy, XJFc, xNctI, iRag, HNWQLN, QShRv, wvLWrR, RBxwC, NJYDw, hnzn, ObaW, GQwi, PEd, QdoPQ, gjcpVV, rpLXZQ, AgOS, JqoiZ, DAtco, yEgO, qLxl, VgxT, ILfKa, MiIKnZ, ghrHCO, SkCh, VZX, cse, CRNg, pKueQH, pBexm, IWsb, lQAKeL, fPA, WKxAMJ, KNu, ndAdX, Iijm, iECVsR, sXHYzn, EzOpkv, vbXHrx, A complex array of signaling molecules and receptors that ensure the appropriate protection repair. 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