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Advanced A.I. thiamine, riboflavin, pyridoxine, folic acid, pantothenic acid, biotin, vitamin B 12, ascorbic acid, P-carotene (pro-vitamin A), ergosterol (pro-vitamin D).However, from economic point of view, it is feasible to produce vitamin B 12, riboflavin, ascorbic acid and p-carotene by microorganisms. Vaccination may be considered for children and adults who are traveling to areas of active cholera transmission. 3, Hagerstown, MD 21742; phone 800-638-3030; fax 301-223-2400. Diabetes is a chronic disease that causes blood sugar levels to rise higher than normal. Introduction to biotechnology Definition: Biotechnology is the use of living systems and organisms to develop or make useful products, or "any technological application that uses biological systems, living organisms or derivatives thereof, to make or modify products or processes for specific use Key Findings. Type 2 diabetes accounts for more than 90% of patients with diabetes and leads to microvascular and macrovascular complications that cause profound psychological and physical distress to both patients and carers and put a huge burden on health-care systems. No medication- antibiotics, vitamins, calcium, etc. Geneva: World Health Organization; 2018 (Draft issued for public consultation in May 2018). 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